As many of you already know my son was very ill and in need of a kidney..This update is to let you know we are no longer looking for a kidney..My son passed on Sept 6,2011..He is now with Jesus even though my heart is broken I must carry on for him....God Bless you all...And thanks to all that tried to help...
For those that are new to my friends my son was born with Bartters Syndrome..Which means his kidneys released all his electrolytes..I was told he would not see 6 but Jesus blessed us with 30 wonderful though very hard years..We spent lots of time in hospitals and had many close calls but my son was a hero till the end..Some days he could not even walk because of the muscle spasms in his legs..They felt like rocks under his skin..But he still tried to get around himself..I will never stop missing him as we were so close and I will shed tears as they come till the day I pass..My life has changed as I knew it and now I am having a very hard time adjusting to the fact he will never walk through my door or sit in my chair which he spent hours in because he said it was most comfortable place for him..I still find myself looking for him not excepting he is gone..This is the hardest thing a Mother can go through..
My Grandson made this for my son in heaven..Please rate and comment it for him...
http://bln.gs/b/24g8g2
MY SONS POEM!!!
If tears could build a stairway,
And memories were a lane,
I would walk right up to heaven
To bring you down again.
No farewell words were spoken,
No time to say good-bye.
You were gone before I knew it,
And only God knows why.
My heart ache in sadness
And secret tears still flow,
What it meant to lose you,
No one will ever know.
When I'm sad and lonely,
And everything goes wrong,
I seem to hear you whisper
"Cheer up and carry on."
Each time I look at your pictures,
You seem to smile and say,
"Don't cry, I'm in Heaven now,
We'll meet again someday
Bartter syndrome is a rare inherited defect in the thick ascending limb of the loop of Henle. It is characterized by low potassium levels (hypokalemia)[1] , increased blood pH (alkalosis), and normal to low blood pressure. There are two types of Bartter syndrome: neonatal and classic. A closely associated disorder, Gitelman syndrome, is milder than both subtypes of Bartter syndrome.
Contents
[hide]
1 Features
2 Diagnosis
3 Pathophysiology
4 Treatment
5 Prognosis
6 History
7 Related conditions
8 References
9 External links
[edit] Features
In 90% of cases, neonatal Bartter syndrome is seen between 24 and 30 weeks of gestation with excess amniotic fluid (polyhydramnios). After birth, the infant is seen to urinate and drink excessively (polyuria, and polydipsia, respectively). Life-threatening dehydration may result if the infant does not receive adequate fluids. About 85% of infants dispose of excess amounts of calcium in the urine (hypercalciuria) and kidneys (nephrocalcinosis), which may lead to kidney stones. In rare occasions, the infant may progress to renal failure.
Patients with classic Bartter syndrome may have symptoms in the first two years of life, but they are usually diagnosed at school age or later. Like infants with the neonatal subtype, patients with classic Bartter syndrome also have polyuria, polydipsia, and a tendency to dehydration, but normal or just slightly increased urinary calcium excretion without the tendency to develop kidney stones. These patients also have vomiting and growth retardation. Kidney function is also normal if the disease is treated,[2] but occasionally patients proceed to end-stage renal failure. Bartter's syndrome consists of hypokalaemia, alkalosis, normal to low blood pressures, and elevated plasma renin and aldosterone. Numerous causes of this syndrome probably exist. Diagnostic pointers include high urinary potassium and chloride despite low serum values, increased plasma renin, hyperplasia of the juxtaglomerular apparatus on renal biopsy, and careful exclusion of diuretic abuse. Excess production of renal prostaglandins is often found. Magnesium wasting may also occur.
[edit] Diagnosis
People suffering from Bartter syndrome present symptoms that are identical to those of patients who are on loop diuretics like furosemide.
The clinical findings characteristic of Bartter syndrome are hypokalemia, metabolic alkalosis, and normal to low blood pressure. These findings may also be caused by:
Chronic vomiting: These patients will have low urine chloride levels (Bartter's will have relatively higher urine chloride levels).
Abuse of diuretic medications (water pills): The physician must screen urine for multiple diuretics before diagnosis is made.
Magnesium deficiency and Calcium deficiency: These patients will also have low serum and urine magnesium and calcium
Patients with Bartter syndrome may also have elevated renin and aldosterone levels.[3]
Prenatal Bartter syndrome can be associated with polyhydramnios.[4]
[edit] Pathophysiology
Bartter syndrome is caused by mutations of genes encoding proteins that transport ions across renal cells in the thick ascending limb of the nephron.[2]
Bartter and Gitelman syndromes can be divided into different subtypes based on the genes involved:[5]
Name Bartter type Associated gene mutations Defect
neonatal Bartter's syndrome type 1 NKCC2 Na-K-2Cl symporter
neonatal Bartter's syndrome type 2 ROMK thick ascending limb K+ channel
classic Bartter's syndrome type 3 CLCNKB Cl- channel
Bartter's syndrome with sensorineural deafness type 4 BSND[6] Cl- channel accessory subunit
Bartter's syndrome associated with autosomal dominant hypocalcemia type 5 CASR[7] activating mutation of the calcium-sensing receptor
Gitelman's syndrome - SLC12A3 (NCCT) Sodium-chloride symporter
[edit] Treatment
While patients should be encouraged to include liberal amounts of sodium[citation needed] and potassium in their diet, potassium supplements are usually required, and spironolactone is also used to reduce potassium loss.[1]
Nonsteroidal antiinflammatory drugs (NSAIDs) can be used as well, and are particularly helpful in patients with neonatal Bartter's syndrome.
Angiotensin-converting enzyme (ACE) inhibitors can also be used.
[edit] Prognosis
The limited prognostic information available suggests that early diagnosis and appropriate treatment of infants and young children with Classic Bartter Syndrome may improve growth and perhaps neurointellectual development. On the other hand, sustained hypokalemia and hyperreninemia can cause progressive tubulointerstitial nephritis, resulting in end-stage-renal disease (Kidney failure). With early treatment of the electrolyte imbalances the prognosis for patients with Classic Bartter Syndrome is good.
[edit] History
The condition is named after Dr. Frederic Bartter, who, along with Dr. Pacita Pronove, first described it in 1960 and in more patients in 1962.[3][8][9][10]
[edit] Related conditions
Bartter and Gitelman syndromes are both characterized by hypokalemia, normal to low blood pressure, and hypochloremic metabolic alkalosis.[11]
Pseudo-Bartter’s syndrome is a syndrome of similar presentation as Bartter syndrome but without any of its characteristic genetic defects. Pseudo-Bartter’s syndrome has been seen in cystic fibrosis,[12] as well as in excessive use of laxatives.[13]
[edit] References
^ a b "Bartter Syndrome: Tubular and Cystic Kidney Disorders: Merck Manual Home Edition". Retrieved 2007-12-31.
^ a b Rodriguez-Soriano J (1998). "Bartter and related syndromes: the puzzle is almost solved". Pediatr Nephrol 12 (4): 315–27. doi:10.1007/s004670050461. PMID 9655365.
^ a b Bartter FC, Pronove P, Gill JR Jr, MacCardle RC (1962). "Hyperplasia of the juxtaglomerular complex with hyperaldosteronism and hypokalemic alkalosis. A new syndrome". Am J Med 33 (6): 811–28. doi:10.1016/0002-9343(62)90214-0. PMID 13969763. Reproduced in Bartter FC, Pronove P, Gill JR, MacCardle RC (1998). "Hyperplasia of the juxtaglomerular complex with hyperaldosteronism and hypokalemic alkalosis. A new syndrome. 1962". J. Am. Soc. Nephrol. 9 (3): 516–28. PMID 9513916.
^ Dane B, Yayla M, Dane C, Cetin A (2007). "Prenatal diagnosis of Bartter syndrome with biochemical examination of amniotic fluid: case report". Fetal. Diagn. Ther. 22 (3): 206–8. doi:10.1159/000098719. PMID 17228161.
^ Naesens M, Steels P, Verberckmoes R, Vanrenterghem Y, Kuypers D (2004). "Bartter's and Gitelman's syndromes: from gene to clinic". Nephron Physiol 96 (3): p65–78. doi:10.1159/000076752. PMID 15056980.
^ Zaffanello M, Taranta A, Palma A, Bettinelli A, Marseglia GL, Emma F (2006). "Type IV Bartter syndrome: report of two new cases". Pediatr. Nephrol. 21 (6): 766–70. doi:10.1007/s00467-006-0090-x. PMID 16583241.
^ Vezzoli G, Arcidiacono T, Paloschi V, et al. (2006). "Autosomal dominant hypocalcemia with mild type 5 Bartter syndrome". J. Nephrol. 19 (4): 525–8. PMID 17048213.
^ Proesmans W (2006). "Threading through the mizmaze of Bartter syndrome". Pediatr. Nephrol. 21 (7): 896–902. doi:10.1007/s00467-006-0113-7. PMID 16773399.
^ synd/2328 at Who Named It?
^ http://www.whonamedit.com/synd.cfm/2328.html
^ Gitelman HJ, Graham JB, Welt LG (1966). "A new familial disorder characterized by hypokalemia and hypomagnesemia". Trans Assoc Am Physicians 79: 221–35. PMID 5929460.
^ Royal Brompton & Harefield Hospital > Pseudo-Bartter’s syndrome Retrieved Mars, 2011
^ Metyas, Samy; Rouman, Heba; Arkfeld, Daniel G. (2010). "Pregnancy in a Patient With Gouty Arthritis Secondary to Pseudo-Bartter Syndrome". JCR: Journal of Clinical Rheumatology 16 (5): 219–220. doi:10.1097/RHU.0b013e3181e9312a. edit
Please vote on the 2 links below, They are tributes to my son...Thank you.
http://bln.gs/b/241vhk
http://bln.gs/b/241pjq
Here is a link to some very nice groups..I love it so please come check it out..I think you might enjoy it also...
http://blingee.com/group/81542-Reflections
http://blingee.com/group/80175-All-That-Sparkles
http://blingee.com/group/81314-Free-Spirit
http://blingee.com/group/50694-Flower-Lovers
http://blingee.com/group/202-Fantasy-land-blingees
http://blingee.com/group/1-Blingee
___♥♥♥______♥♥♥_____ Put this
__♥_____♥_♥_____♥___ heart
__♥______♥______♥___ on your
___♥___Blingee__♥____page if you
_____♥_______♥______ love
_______♥___♥________ Blingee!
_________♥__________xxxxxxxx
XXXXXXXXXXXXXXXXXXXXXXXXXXXX
─▀██▀─▄███▄─▀██─██▀██▀▀▀█─
──██─███─███─██─██─██▄█──
──██─▀██▄██▀─▀█▄█▀─██▀█──
─▄██▄▄█▀▀▀─────▀──▄██▄▄▄█
τнιṡ!!! ♥➷♥ 5*
♪♫•*¨*•.¸¸❤¸¸.•*¨*•♫♪
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
╔══╗╔╗
╚╗╔╝║║╔═╦╦╦═╗╔╦══╗
╔╝╚╗║╚╣║║║║╩╣║╠╗╔╝
╚══╝╚═╩═╩═╩═╝╚╝╚╝
☆★☆★☆ 5 STARS ★☆★☆★☆
ღ♥♥ღ♥ღ♥♥ღ♥ღ♥ღ♥♥ღ♥ღ♥ღ♥♥ღ
╔═╦═╦═╦══╦═╦═╦══╦╦═╗
║═╣║║║╠╗╔╣║║╚╬╗╔╣║╔╝
║╔╣╦║║║║║║╦╠╗║║║║║╚╗
╚╝╚╩╩╩╩╩╩╩╩╩═╩╩╩╩╩═╝
ღ♥♥ღ♥ღ♥♥ღ♥ღ♥ღ♥♥ღ♥ღ♥ღ♥♥ღ
W♥O♥N♥D♥E♥R♥F♥U♥L
╔═╦═╦═╦═╦══╦╦╦╦═╗║
║╠╣╔╣╩╣╬╠╗╔╬╣║║╩╣║
╚═╩╝╚═╩╩╝╚╝╚╩═╩═╝๏
B♥E♥A♥U♥T♥I♥F♥U♥L
THE ACCIDENT
By: Beverly Czerwinski
I was driving down the road last night as I looked into this car,
And saw a child not buckled up as his dad pulled out of the bar.
He had a beer in his hand and wasn't driving very straight,
My heart suddenly filled up with so much anger and hate.
Nobody saw it coming the car began to roll,
And it did not stop until it hit the pole.
Paramedics were called and I stayed there until they came,
Knowing the father was drunk and he was to blame.
The child did not make it and neither did the dad,
It was such a terrible night, everyone was so sad.
This could have been avoided if the dad didn't drink and drive,
That poor little child would still be alive.
A Handy Reference List Of Emergency Phone Numbers:
Problem
Call:
When in sorrow
John 14
When men fail you
Psalm 27
When you have sinned
Psalm 51
When you worry
Matthew 6:19-34
When you are in danger
Psalm 91
When God seems far away
Psalm 139
When your faith needs stirring
Hebrews 11
When you are lonely and fearful
Psalm 23
When you grow bitter and critical
I Corinthians 13
When you feel down and out
Romans 8:31
When you want peace and rest
Matthew 11:25-30
When the world seems bigger than God
Psalm 90
When you want Christian assurance
Romans 8:1-30
When you leave home for labor or travel
Psalm 121
When your prayers grow narrow or selfish
Psalm 67
When you want courage for a task
Joshua 1
When you think of investments and returns
Mark 10
If you are depressed
Psalm 27
If your pocketbook is empty
Psalm 37
If you are losing confidence in people
I Corinthians 13
If people seem unkind
John 15
If discouraged about your work
Psalm 126
If self pride/greatness takes hold
Psalm 19
If you want to be fruitful
John 15
For understanding of Christianity
II Corinthians 5:15-19
For a great invention/opportunity
Isaiah 55
For how to get along with fellow men
Romans 12
For Paul's secret to happiness
Colossians 3:12-17
ALTERNATE NUMBERS:
For dealing with fear
Psalm 34:7
For security
Psalm 121:3
For assurance
Mark 8:35
For reassurance
Psalm 145:18
PLEASE NOTE:
Emergency numbers may be dialed direct.
No operator assistance is necessary.
All lines to Heaven are open 24 hours a day!